# Department Seminars & Colloquia

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B378 Seminar room, IBS HQ
IBS-KAIST Seminar
Hang Joon Kim (University of Cincinnati)
Introduction to Bayesian Variable Selection

B378 Seminar room, IBS HQ

IBS-KAIST Seminar

Variable selection is an approach to identifying a set of covariates that are truly important to explain the feature of a response variable. It is closely connected or belongs to model selection approaches. This talk provides a gentle introduction to Bayesian variable selection methods. The basic notion of variable selection is introduced, followed by several Bayesian approaches with a simple application example.

Morihiko Saito's theory of mixed Hodge modules is a far generalisation of classical Hodge theory, which is based on the theory of perverse sheaves, D-modules, variations of Hodge structures. One can think of mixed Hodge modules as a certain class of D-modules with Hodge structures. Naturally they are accompanied by perverse sheaves via the Riemann–Hilbert correspondence. This guide consists of about 8 talks, which may cover: review of classical Hodge theory, D-modules and filtered D-modules, nearby and vanishing cycles, etc. The main goal is to understand the notion of mixed Hodge modules and to explain two important theorems: the structure theorem and the direct image theorem. If time permits, we discuss recent applications of the theory in algebraic geometry.

zoom 정보는 강연 며칠 전에 이곳에 공개될 예정입니다. 총 8회의 강연을 계획중이고 매주 금요일 1회씩 진행하여 3월 말- 4월 초까지 진행할 계획입니다.

zoom 정보는 강연 며칠 전에 이곳에 공개될 예정입니다. 총 8회의 강연을 계획중이고 매주 금요일 1회씩 진행하여 3월 말- 4월 초까지 진행할 계획입니다.

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Room B232, IBS (기초과학연구원)
Discrete Mathematics
O-joung Kwon (Incheon National University / IBS DIMAG)
Reduced bandwidth: a qualitative strengthening of twin-width in minor-closed classes (and beyond)

Room B232, IBS (기초과학연구원)

Discrete Mathematics

In a reduction sequence of a graph, vertices are successively identified until the graph has one vertex. At each step, when identifying $u$ and $v$, each edge incident to exactly one of $u$ and $v$ is coloured red. Bonnet, Kim, Thomassé, and Watrigant [FOCS 2020] defined the twin-width of a graph $G$ to be the minimum integer $k$ such that there is a reduction sequence of $G$ in which every red graph has maximum degree at most $k$. For any graph parameter $f$, we define the reduced-$f$ of a graph $G$ to be the minimum integer $k$ such that there is a reduction sequence of $G$ in which every red graph has $f$ at most $k$. Our focus is on graph classes with bounded reduced-bandwidth, which implies and is stronger than bounded twin-width (reduced-maximum-degree).
We show that every proper minor-closed class has bounded reduced-bandwidth, which is qualitatively stronger than a result of Bonnet et al. for bounded twin-width. In many instances, we also make quantitative improvements. For example, all previous upper bounds on the twin-width of planar graphs were at least $2^{1000}$. We show that planar graphs have reduced-bandwidth at most $466$ and twin-width at most $583$; moreover, the witnessing reduction sequence can be constructed in polynomial time. We show that $d$-powers of graphs in a proper minor-closed class have bounded reduced-bandwidth (irrespective of the degree of the vertices).
This is joint work with Édouard bonnet and David Wood.

This seminar has two purposes. One is to understand the nature of finance and the current international monetary order that contributed to the root cause of the global financial crisis. They are the financial system risk caused by maturity transformation, which is the core of the financial activity, the procyclicality of finance in which credit expands in an asset market boom and shrinks in a recession, and safe assets, etc. Another is to understand the ripple effect of the 21st century digital technology revolution. Just as cryptocurrencies cause conflicts with states monopolizing creating money, currencies based on digital platforms are causing conflicts with existing finance by shifting the core function of finance from intermediation to payment and settlement. Moreover, the democratization of finance thanks to the development of digital technology is another conflicting factor against the existing elite-centered finance, where the financial elite evaluates risks and receives rewards. Along with asset inflation, the pandemic has significantly increased debt on the one hand and accelerated the digitalization of finance on the other. The challenge in the post-pandemic era is to normalize increased debt and liquidity to a sustainable level while minimizing economic costs, and to come up with an alternative solution to the dilemma of the dollar-centered international monetary order. The first day of the seminar will focus on the attributes of finance, and the second day will discuss the challenges facing finance in the post-pandemic era and the digitalization of finance.

2개 세션으로 나누어 진행

2개 세션으로 나누어 진행

2개 세션으로 나누어 진행

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B378 Seminar room, IBS HQ
Math Biology
Minseok Seo (Korea University)
Current status of multi-omics research field and necessity of gene-by-environment (GxE) interaction modeling

B378 Seminar room, IBS HQ

Math Biology

본 발표에서는 다양한 기초 생명-의학 분야에서 생성되고 있는 오믹스 자료의 연구 개발 현황에 대해서 다룰 예정이다. 보다 큰 규모로, 보다 빠르게, 보다 정확하게, 보다 정밀하게 라는 궁극적인 목표하에 이뤄지고 있는 오믹스 자료의 진화에 발맞춰, 이를 분석하는 수리통계적 모형 역시 진화하고 있다. 그 중, 이번 발표에서는 미국의 초 대형 정밀의료 프로젝트인 TopMed에서 진행하고 있는 COPD에 관한 다중 오믹스 자료의 통합 분석 방법 및 결과에 대해서 자세히 다룰 예정이다. 아울러 정밀의료라는 목표를 달성하기 위해 반드시 모형에서 고려해야 하는 “환경 특이적 효과”에 대해 강연할 예정이다.

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Room B232, IBS (기초과학연구원)
Discrete Mathematics
Jaehyeon Seo (KAIST)
A rainbow Turán problem for color-critical graphs

Room B232, IBS (기초과학연구원)

Discrete Mathematics

For given $k$ graphs $G_1,\dots, G_k$ over a common vertex set of size $n$, what conditions on $G_i$ ensures a 'colorful' copy of $H$, i.e. a copy of $H$ containing at most one edge from each $G_i$?
Keevash, Saks, Sudakov, and Verstraëte defined $\operatorname{ex}_k(n,H)$ to be the maximum total number of edges of the graphs $G_1,\dots, G_k$ on a common vertex set of size $n$ having no colorful copy of $H$. They completely determined $\operatorname{ex}_k(n,K_r)$ for large $n$ by showing that, depending on the value of $k$, one of the two natural constructions is always the extremal construction. Moreover, they conjectured the same holds for every color-critical graphs and proved it for $3$-color-critical graphs.
We prove their conjecture for $4$-color-critical graphs and for almost all $r$-color-critical graphs when $r > 4$. Moreover, we show that for every non-color-critical non-bipartite graphs, none of the two natural constructions is extremal for certain values of $k$. This is a joint work with Debsoumya Chakraborti, Jaehoon Kim, Hyunwoo Lee, and Hong Liu.

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Room B232, IBS (기초과학연구원)
Discrete Mathematics
Andreas Holmsen (KAIST)
Some recent results on geometric transversals

Room B232, IBS (기초과학연구원)

Discrete Mathematics

A geometric transversal to a family of convex sets in $\mathbb R^d$ is an affine flat that intersects the members of the family. While there exists a far-reaching theory concerning 0-dimensional transversals (intersection patterns of convex sets), much less is known when it comes to higher dimensional transversals. In this talk I will present some new and old results and problems regarding geometric transversals, based on joint work with Otfried Cheong and Xavier Goaoc.

The ions in a fully ionized electrostatic plasma are described by the Euler-Poisson system with the Boltzmann relation. We numerically observe the behavior of solutions to the 1D Euler-Poisson system for various initial data and how solitary waves and singularities are developed. We also introduce some results on the linear stability of solitary waves and the formation of singularities. These are joint works with Junho Choi and Bongsuk Kwon.

Inside living cells, chemical reactions form a large web of networks. Understanding the behavior of those complex reaction networks is an important and challenging problem. In many situations, it is hard to identify the details of the reactions, such as the reaction kinetics and parameter values. It would be good if we can clarify what we can say about the behavior of reaction systems, when we know the structure of reaction networks but reaction kinetics is unknown. In these talks, I plan to introduce two approaches in this spirit. Firstly, we will discuss the sensitivity analysis of reaction systems based on the structural information of reaction networks [1]. I will give an introduction to the method of identifying subnetworks inside which the effects of the perturbation of reaction parameters are confined. Secondly, I will introduce the reduction method that we developed recently [2]. In those two methods, an integer determined by the topology of a subnetwork, which we call an influence index, plays a crucial role.
[1] T. Okada, A. Mochizuki, “Law of Localization in Chemical Reaction Networks,” Phys. Rev. Lett. 117, 048101 (2016); T. Okada, A. Mochizuki, “Sensitivity and network topology in chemical reaction systems,” Phys. Rev. E 96, 022322 (2017).
[2] Y. Hirono, T. Okada, H. Miyazaki, Y. Hidaka, “Structural reduction of chemical reaction networks based on topology”, Phys. Rev. Research 3, 043123 (2021).

Abstract: Inside living cells, chemical reactions form a large web of networks. Understanding the behavior of those complex reaction networks is an important and challenging problem. In many situations, it is hard to identify the details of the reactions, such as the reaction kinetics and parameter values. It would be good if we can clarify what we can say about the behavior of reaction systems, when we know the structure of reaction networks but reaction kinetics is unknown. In these talks, I plan to introduce two approaches in this spirit. Firstly, we will discuss the sensitivity analysis of reaction systems based on the structural information of reaction networks [1]. I will give an introduction to the method of identifying subnetworks inside which the effects of the perturbation of reaction parameters are confined. Secondly, I will introduce the reduction method that we developed recently [2]. In those two methods, an integer determined by the topology of a subnetwork, which we call an influence index, plays a crucial role.
References
[1] T. Okada, A. Mochizuki, “Law of Localization in Chemical Reaction Networks,” Phys. Rev. Lett. 117, 048101 (2016); T. Okada, A. Mochizuki, “Sensitivity and network topology in chemical reaction systems,” Phys. Rev. E 96, 022322 (2017).
[2] Y. Hirono, T. Okada, H. Miyazaki, Y. Hidaka, “Structural reduction of chemical reaction networks based on topology”, Phys. Rev. Research 3, 043123 (2021).

In adult tissues, stem cells undergo clonal competition because they proliferate while the stem cell niche provides limited space. This clonal competition allows the selection of healthy stem cells over time as unfit stem cells tend to lose from the competition. It could also be a mechanism to select a supercompetitor with tumorigenic mutations, which may lead to tumorigenesis. I am going to explain general concepts of clonal competition and how a simple model can explain the behaviour of adult stem cells. I will also show how geometric constraints affect the overall dynamics of stem cell competition.

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Room B232, IBS (기초과학연구원)
Discrete Mathematics
Seunghun Lee (Binghamton University)
Transversals and colorings of simplicial spheres

Room B232, IBS (기초과학연구원)

Discrete Mathematics

Motivated from the surrounding property of a point set in $\mathbb{R}^d$ introduced by Holmsen, Pach and Tverberg, we consider the transversal number and chromatic number of a simplicial sphere. As an attempt to give a lower bound for the maximum transversal ratio of simplicial $d$-spheres, we provide two infinite constructions. The first construction gives infinitely many $(d+1)$-dimensional simplicial polytopes with the transversal ratio exactly $\frac{2}{d+2}$ for every $d\geq 2$. In the case of $d=2$, this meets the previously well-known upper bound $1/2$ tightly. The second gives infinitely many simplicial 3-spheres with the transversal ratio greater than $1/2$. This was unexpected from what was previously known about the surrounding property. Moreover, we show that, for $d\geq 3$, the facet hypergraph $\mathcal{F}(\mathbf{P})$ of a $(d+1)$-dimensional simplicial polytope $\mathbf{P}$ has the chromatic number $\chi(\mathcal{F}(\mathbf{P})) \in O(n^{\frac{\lceil d/2\rceil-1}{d}})$, where $n$ is the number of vertices of $\mathbf{P}$. This slightly improves the upper bound previously obtained by Heise, Panagiotou, Pikhurko, and Taraz. This is a joint work with Joseph Briggs and Michael Gene Dobbins.