Sunday, July 3, 2022

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2022-07-05 / 16:00 ~ 17:00
IBS-KAIST 세미나 - 수리생물학: 인쇄
by ()
Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation is still challenging. Here, we suggest an integrative strategy called TENET+ by combining single cell transcriptome and chromatin accessibility data. By applying TENET+ to a paired scRNAseq and scATACseq dataset of human peripheral blood mononuclear cells, we found critical regulators and their epigenetic regulations for the differentiations of CD4 T cells, CD8 T cells, B cells and monocytes. Interestingly, TENET+ predicted LRRFIP1 and ZBTB16 as top regulators of CD4 and CD8 T cells which were not predicted in a motif-based tool SCENIC. In sum, TENET+ is a tool predicting epigenetic gene regulatory programs in unbiased way, suggesting that novel epigenetic regulations can be identified by TENET+.
2022-07-05 / 16:00 ~ 17:00
IBS-KAIST 세미나 - 수리생물학: 인쇄
by ()
Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation is still challenging. Here, we suggest an integrative strategy called TENET+ by combining single cell transcriptome and chromatin accessibility data. By applying TENET+ to a paired scRNAseq and scATACseq dataset of human peripheral blood mononuclear cells, we found critical regulators and their epigenetic regulations for the differentiations of CD4 T cells, CD8 T cells, B cells and monocytes. Interestingly, TENET+ predicted LRRFIP1 and ZBTB16 as top regulators of CD4 and CD8 T cells which were not predicted in a motif-based tool SCENIC. In sum, TENET+ is a tool predicting epigenetic gene regulatory programs in unbiased way, suggesting that novel epigenetic regulations can be identified by TENET+.
2022-07-05 / 16:00 ~ 17:00
IBS-KAIST 세미나 - 수리생물학: 인쇄
by ()
Reconstruction of gene regulatory networks (GRNs) is a powerful approach to capture a prioritized gene set controlling cellular processes. In our previous study, we developed TENET a GRN reconstructor from single cell RNA sequencing (scRNAseq). TENET has a superior capability to identify key regulators compared with other algorithms. However, accurate inference of gene regulation is still challenging. Here, we suggest an integrative strategy called TENET+ by combining single cell transcriptome and chromatin accessibility data. By applying TENET+ to a paired scRNAseq and scATACseq dataset of human peripheral blood mononuclear cells, we found critical regulators and their epigenetic regulations for the differentiations of CD4 T cells, CD8 T cells, B cells and monocytes. Interestingly, TENET+ predicted LRRFIP1 and ZBTB16 as top regulators of CD4 and CD8 T cells which were not predicted in a motif-based tool SCENIC. In sum, TENET+ is a tool predicting epigenetic gene regulatory programs in unbiased way, suggesting that novel epigenetic regulations can be identified by TENET+.
2022-07-05 / 16:00 ~ 17:00
학과 세미나/콜로퀴엄 - 정수론: 인쇄
by ()
The degree-shifting action on the cohomology of locally symmetric spaces, which has its origins in the representation theory of real reductive groups, enjoys a surprising connection with arithmetic, as expected by the so-called motivic action conjectures of A. Venkatesh. Although these conjectures are expected to hold in great generality, there is a disparity between the algebraic and non-algebraic locally symmetric spaces. We will discuss the nature of the degree-shifting action in both cases (For those who cannot attend the in-person seminar, we will also stream the seminar talk via Zoom. Please contact Wansu Kim for the Zoom connection details.)
2022-07-06 / 16:30 ~ 18:00
학과 세미나/콜로퀴엄 - 계산수학 세미나: 인쇄
by 최재규()
Recently, mapping a signal/image into a low rank Hankel/Toeplitz matrix has become an emerging alternative to the traditional sparse regularization, due to its ability to alleviate the basis mismatch between the true support in the continuous domain and the discrete grid. In this talk, we introduce a novel structured low rank matrix framework to restore piecewise smooth functions. Inspired by the total generalized variation to use sparse higher order derivatives, we derive that the Fourier samples of higher order derivatives satisfy an annihilation relation, resulting in a low rank multi-fold Hankel matrix. We further observe that the SVD of a low rank Hankel matrix corresponds to a tight wavelet frame system which can represent the image with sparse coefficients. Based on this observation, we also propose a wavelet frame analysis approach based continuous domain regularization model for the piecewise smooth image restoration.
2022-07-04 / 16:30 ~ 17:30
IBS-KAIST 세미나 - 이산수학: Computational phase transition and MCMC algorithms 인쇄
by Eric Vigoda(UC Santa Barbara)
This talk will highlight recent results establishing a beautiful computational phase transition for approximate counting/sampling in (binary) undirected graphical models (such as the Ising model or on weighted independent sets). The computational problem is to sample from the equilibrium distribution of the model or equivalently approximate the corresponding normalizing factor known as the partition function. We show that when correlations die off on the infinite D-regular tree then the Gibbs sampler has optimal mixing time of O(n log n) on any graph of maximum degree D, whereas when the correlations persist (in the limit) then the sampling/counting problem are NP-hard to approximate. The Gibbs sampler is a simple Markov Chain Monte Carlo (MCMC) algorithm. Key to these mixing results are a new technique known as spectral independence which considers the pairwise influence of vertices. We show that spectral independence implies an optimal convergence rate for a variety of MCMC algorithms.
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