For a given stable subalgebra of the formal power series ring, its Laurent extension, or others, we define an operator algebra over the subalgebra. One of the important operator algebras is the Weyl algebra or its generalization. We define generalized radical Weyl algebras (GRWA) and define the generalized radical Weyl algebra modules, we prove that the algebras and modules are simple. An automorphism of the GRWA define a twisted simple module as well. Since GRWA is an associative algebra, it has an ${\Bbb F}$-subalgebra which is a Lie algebra with respect to the commutator and we show that the Lie algebra is simple. We consider some other generalized Weyl algebra and its descended consequences as well.
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