Saturday, May 11, 2024

2024-05-17 / 14:00 ~ 16:00

by 황규영(IBS 의생명수학그룹)

"Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming", Cell (2019) will be discussed in this Journal Club. Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddington-OT, an approach for studying developmental time courses to infer ancestor-descendant fates and model the regulatory programs that underlie them. We apply the method to reconstruct the landscape of reprogramming from 315,000 single-cell RNA sequencing (scRNA-seq) profiles, collected at half-day intervals across 18 days. The results reveal a wider range of developmental programs than previously characterized. Cells gradually adopt either a terminal stromal state or a mesenchymal-to-epithelial transition state. The latter gives rise to populations related to pluripotent, extra-embryonic, and neural cells, with each harboring multiple finer subpopulations. The analysis predicts transcription factors and paracrine signals that affect fates and experiments validate that the TF Obox6 and the cytokine GDF9 enhance reprogramming efficiency. Our approach sheds light on the process and outcome of reprogramming and provides a framework applicable to diverse temporal processes in biology. If you want to participate in the seminar, you need to enter IBS builiding (https://www.ibs.re.kr/bimag/visiting/). Please contact if you first come IBS to get permission to enter IBS building.

2024-05-16 / 16:30 ~ 18:30

학과 세미나/콜로퀴엄 - 기타:

by 김준범, 김정섭 (Samsung Research), 심규석(행정안전부)()

1. 데이터 분석 업무의 이해(김준범)- 데이터 분석가의 역할 소개 2. 초거대 언어 모델 동향(김정섭)-GPT-3 부터 Llama-3까지 이미 우리 삶 속에 깊숙이 자리잡은 초거대 언어 모델의 동향 3. 데이터 분석가에서 공직으로 오게된 과정과 앞으로의 계획(심규석)- 삼성화재에서의 데이터 분석 및 AI 모델링 업무, 행정안전부에서의 데이터 분석과제 기획·관리 및 공무원의 데이터 분석 역량지원 업무 전반에 관한 설명과 함께 각 기관을 지원하게 된 동기, 지원방법, 준비사항 등

2024-05-17 / 14:00 ~ 16:00

학과 세미나/콜로퀴엄 - 기타: Introduction to étale cohomology 5

by 이제학(KAIST)

This is an introductory reading seminar presented by a senior undergraduate student, Jaehak Lee, who is studying the subject.

2024-05-14 / 16:30 ~ 17:30

IBS-KAIST 세미나 - 이산수학: Cross-cap drawings and signed reversal distance

by Niloufar Fuladi(Inria center of Université de Lorraine)

A cross-cap drawing of a graph G is a drawing on the sphere with g distinct points, called cross-caps, such that the drawing is an embedding except at the cross-caps, where edges cross properly. A cross-cap drawing of a graph G with g cross-caps can be used to represent an embedding of G on a non-orientable surface of genus g. Mohar conjectured that any triangulation of a non-orientable surface of genus g admits a cross-cap drawing with g cross-caps in which each edge of the triangulation enters each cross-cap at most once. Motivated by Mohar’s conjecture, Schaefer and Stefankovic provided an algorithm that computes a cross-cap drawing with a minimal number of cross-caps for a graph G such that each edge of the graph enters each cross-cap at most twice. In this talk, I will first outline a connection between cross-cap drawings and an algorithm coming from computational biology to compute the signed reversal distance between two permutations. This connection will then be leveraged to answer two computational problems on graphs embedded on surfaces. First, I show how to compute a “short” canonical decomposition for a non-orientable surface with a graph embedded on it. Such canonical decompositions were known for orientable surfaces, but the techniques used to compute them do not generalize to non-orientable surfaces due to their more complex nature. Second, I explain how to build a counter example to a stronger version of Mohar’s conjecture that is stated for pseudo-triangulations. This is joint work with Alfredo Hubard and Arnaud de Mesmay.

2024-05-16 / 11:50 ~ 12:40

대학원생 세미나 - 대학원생 세미나: Deformations of Coxeter orbifolds

by 박승열(KAIST)

Given a smooth manifold or orbifold M and a Lie group G acting transitively on a space X, we consider the space of all (G, X)-structures on M up to an appropriate equivalence relation. This space, known as the deformation space of (G, X)-structures on M, encodes information about how one can "deform" the (G, X)-manifold M. In this talk, I will provide a general definition of deformation spaces and character varieties, which capture the local structure of the deformation space. Additionally, I will introduce a class of orbifolds called the Coxeter orbifolds, for which deformation spaces can be computed using an approach due to the foundational work of E. Vinberg.

Events for the 취소된 행사 포함