Friday, June 14, 2024

2024-06-19 / 10:00 ~ 11:00

by ()

Pressure functions are key ideas in the thermodynamic formalism of dynamical systems. McMullen used the convexity of the pressure function to construct a metric, called a pressure metric, on the Teichmuller space and showed that it is a constant multiple of the Weil-Petersson metric. In the spirit of Sullivan's dictionary, McMullen applied the same idea to define a metric on the space of Blaschke products. In this talk, we will discuss Bridgeman-Taylor and McMullen's earlier works on the pressure metric, as well as recent developments in more generic settings. Then we will talk about pressure metrics on hyperbolic components in complex dynamics, as well as unsolved problems.

2024-06-18 / 10:00 ~ 11:00

학과 세미나/콜로퀴엄 - 위상수학 세미나:

by ()

When does a topological branched self-covering of the sphere enjoy a holomorphic structure? William Thurston answered this question in the 1980s by using a holomorphic self-map of the Teichmuller space known as Thurston's pullback map. About 30 years later, Dylan Thurston took a different approach to the same question, reducing it to a one-dimensional dynamical problem. We will discuss both characterizations and their applications to various questions in complex dynamics.

2024-06-21 / 14:00 ~ 16:00

IBS-KAIST 세미나 - IBS-KAIST 세미나:

by (IBS 의생명수학그룹)

In this talk, we will discuss the paper, “Computational screen for sex-specific drug effects in a cardiac fibroblast signaling network model”, by K.M. Watts, W. Nichols and W.J. Richardson, Scientific Reports, 2023. Abstract Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the progression of heart failure, and there are currently no drugs approved specifically to target matrix accumulation in the heart. Computational signaling network models (SNMs) can be used to facilitate discovery of novel drug targets. However, the vast majority of SNMs are not sex-specific and/or are developed and validated using data skewed towards male in vitro and in vivo samples. Biological sex is an important consideration in cardiovascular health and drug development. In this study, we integrate a cardiac fibroblast SNM with estrogen signaling pathways to create sex-specific SNMs. The sex-specific SNMs demonstrated high validation accuracy compared to in vitro experimental studies in the literature while also elucidating how estrogen signaling can modulate the effect of fibrotic cytokines via multi-pathway interactions. Further, perturbation analysis and drug screening uncovered several drug compounds predicted to generate divergent fibrotic responses in male vs. female conditions, which warrant further study in the pursuit of sex-specific treatment recommendations for cardiac fibrosis. Future model development and validation will require more generation of sex-specific data to further enhance modeling capabilities for clinically relevant sex-specific predictions of cardiac fibrosis and treatment.

2024-06-14 / 14:00 ~ 16:00

IBS-KAIST 세미나 - IBS-KAIST 세미나:

by 김현(IBS 의생명수학그룹)

In this talk, we discuss the paper, “Powerful and accurate detection of temporal gene expression patterns from multi-sample multi-stage single-cell transcriptomics data with TDEseq” by Y. Fan, L. Li and S. Sun, Genome Biology, 2024. Abstract We present a non-parametric statistical method called TDEseq that takes full advantage of smoothing splines basis functions to account for the dependence of multiple time points in scRNA-seq studies, and uses hierarchical structure linear additive mixed models to model the correlated cells within an individual. As a result, TDEseq demonstrates powerful performance in identifying four potential temporal expression patterns within a specific cell type. Extensive simulation studies and the analysis of four published scRNA-seq datasets show that TDEseq can produce well-calibrated p-values and up to 20% power gain over the existing methods for detecting temporal gene expression patterns. If you want to participate in the seminar, you need to enter IBS builiding (https://www.ibs.re.kr/bimag/visiting/). Please contact jaekkim@kaist.ac.kr if you first come IBS to get permission to enter IBS building.

2024-06-18 / 16:30 ~ 17:30

IBS-KAIST 세미나 - 이산수학: Paley-like quasi-random graphs arising from polynomials

by 유세민(IBS 이산수학그룹)

We provide new constructions of families of quasi-random graphs that behave like Paley graphs but are neither Cayley graphs nor Cayley sum graphs. These graphs give a unified perspective of studying various graphs defined by polynomials over finite fields, such as Paley graphs, Paley sum graphs, and graphs associated with Diophantine tuples and their generalizations from number theory. As an application, we provide new lower bounds on the clique number and independence number of general quasi-random graphs. In particular, we give a sufficient condition for the clique number of quasi-random graphs of order $n$ to be at least $(1-o(1))\log_{3.008}n$. Such a condition applies to many classical quasi-random graphs, including Paley graphs and Paley sum graphs, as well as some new Paley-like graphs we construct. If time permits, we also discuss some problems of diophantine tuples arising from number theory, which is our original motivation. This is joint work with Seoyoung Kim and Chi Hoi Yip.

2024-06-21 / 14:00 ~ 16:00

학과 세미나/콜로퀴엄 - 기타: Introduction to complex algebraic geometry and Hodge theory #7

by 김재홍(KAIST)

This is part of an informal seminar series to be given by Mr. Jaehong Kim, who has been studying the book "Hodge theory and Complex Algebraic Geometry Vol 1 by Claire Voisin" for a few months. There will be 6-8 seminars during Spring 2024, and it will summarize about 70-80% of the book.

2024-06-21 / 11:00 ~ 12:00

학과 세미나/콜로퀴엄 - 응용수학 세미나:

by 유기성()

A major trajectory in the development of statistical learning has been the expansion of mathematical spaces underlying observed data, extending from numbers to vectors, functions, and beyond. This expansion has fostered significant theoretical and computational breakthroughs. One notable direction involves analyzing sets where each set becomes an object of interest for inference. This perspective accommodates the intrinsic and non-ignorable heterogeneity inherent in data-generating processes. Among various theoretical frameworks to analyze sets, a principled approach is viewing a set as an empirical measure. In this talk, I revisit the concept of the median - a robust alternative to the mean as a centroid - and introduce a novel extension of this concept within the space of probability measures under the framework of optimal transport. I will present theoretical results and a generic computational pipeline that leverages existing algorithmic developments in the field, with examples. Furthermore, the potential benefits of this novel approach for scalable inference and scientific discovery will be explored.

2024-06-20 / 16:00 ~ 17:00

학과 세미나/콜로퀴엄 - 기타:

by 최인혁(고등과학원 Post-Doc, Cornell University Post-Doc(부임 예정))

박사후 연구 이야기- 박사과정 이후의 삶을 대비하는 방법, 국내 및 해외에서의 박사후연구원 생활과 필요한 준비사항 등

Events for the 취소된 행사 포함